The formalin test does not probe inflammatory pain but excitotoxicity in rodent skin

T Hoffmann, F Klemm, TI Kichko, SK Sauer… - Physiological …, 2022 - Wiley Online Library
… used formalin test to screen antinociceptive drug candidates is … In addition, immediate paw
swelling, plasma extravasation … transient antinociceptive opioid effect but occurred delayed at …

Systemic administration of dorsomorphin relieves inflammatory nociception in the mouse formalin test

Y Xinqiang, J Yuanyuan, Y Zhipeng, K Jie… - International …, 2022 - Elsevier
… , thus we think that the antinociceptive effect of dorsomorphin is … before the CFA significantly
delayed the onset of the … In the present study, we found that formalin induced paw edema

Ulinastatin exhibits antinociception in rat models of acute somatic and visceral pain through inhibiting the local and central inflammation

MX Zhan, L Tang, YF Lu, HH Wu, ZB Guo… - Journal of Pain …, 2021 - Taylor & Francis
… Moreover, ip administration of ulinastatin was also able to delay the occurrence of … Display
full size … ulinastatin could also persistently inhibit formalin-induced paw edema and ulcer …

Anti-inflammatory and antinociceptive effects, and safety toxicological profile of a new paracetamol analog, LQFM291

LC Turones, LS Machado, BG Vaz… - …, 2023 - Springer
… paracetamol showed a similar antinociceptive effect in formalin test compared to LQFM291.
… and edema tests were performed, paracetamol showed a delayed antinociceptive and anti-…

[HTML][HTML] … of Cajanus cajan (L) Millsp. produced antinociceptive and anti-inflammatory actions through inhibition of inflammatory mediators and activation of opioidergic …

TG Olubodun-Obadun, IO Ishola, CA Osumuo… - Phytomedicine Plus, 2023 - Elsevier
… the early and late phases of formalin-induced inflammatory pain… , we did not observe any
sign of toxic behaviour nor delayed … In this study, the oedema formation was maximal at 5 h after …

The antinociceptive effect of adalimumab, a TNF-alpha inhibitor, in a mice model of inflammatory pain

ÖZ Mehmet, H Şimşek - Türk Doğa ve Fen Dergisi, 2020 - dergipark.org.tr
… pulmonary edema and histological damage due to … This test is based on recording the
delay in the experimental … adalimumab has an antinociceptive effect in the formalin test. …

Neo-clerodane diterpenic influence in the antinociceptive and anti-inflammatory properties of Salvia circinnata Cav.

MP Fernando, HL Alberto, VDM Guadalupe… - Journal of …, 2021 - Elsevier
… using the plantar test and carrageenan-induced edema. The … was a beam emitted by a
caloric source with an intensity of … treatments in the formalin test in contrast to a delay of almost …

[HTML][HTML] The CB2 agonist β-caryophyllene in male and female rats exposed to a model of persistent inflammatory pain

I Ceccarelli, P Fiorenzani, F Pessina, J Pinassi… - Frontiers in …, 2020 - frontiersin.org
… injection site were graded as mild (low degree of edema and … next painful events, we carried
out two formalin tests separated … a delay in wound healing (as in the present study) and may

[HTML][HTML] Anti-inflammatory, antinociceptive and antidiarrhoeal activities of methanol and ethyl acetate extract of Hemigraphis alternata leaves in mice

SM Rahman, M Atikullah, MN Islam, M Mohaimenul… - Clinical …, 2019 - Springer
… induced ear edema in Swiss albino mice are documented in Table 2. The percentage of ear
Formalin induced-paw licking is the biphasic pain response system. In the delayed phase, …

Antinociceptive and anti-inflammatory effect of Naringenin in different nociceptive and inflammatory mice models

N Xue, X Wu, L Wu, L Li, F Wang - Life sciences, 2019 - Elsevier
… Carrageenan-induced paw edema test was performed to … The analgesics morphine delays
the tail withdrawal of mice from … significantly decreased the number formalin induced licks in …