The formalin test does not probe inflammatory pain but excitotoxicity in rodent skin
T Hoffmann, F Klemm, TI Kichko, SK Sauer… - Physiological …, 2022 - Wiley Online Library
… used formalin test to screen antinociceptive drug candidates is … In addition, immediate paw
swelling, plasma extravasation … transient antinociceptive opioid effect but occurred delayed at …
swelling, plasma extravasation … transient antinociceptive opioid effect but occurred delayed at …
Systemic administration of dorsomorphin relieves inflammatory nociception in the mouse formalin test
Y Xinqiang, J Yuanyuan, Y Zhipeng, K Jie… - International …, 2022 - Elsevier
… , thus we think that the antinociceptive effect of dorsomorphin is … before the CFA significantly
delayed the onset of the … In the present study, we found that formalin induced paw edema …
delayed the onset of the … In the present study, we found that formalin induced paw edema …
Ulinastatin exhibits antinociception in rat models of acute somatic and visceral pain through inhibiting the local and central inflammation
MX Zhan, L Tang, YF Lu, HH Wu, ZB Guo… - Journal of Pain …, 2021 - Taylor & Francis
… Moreover, ip administration of ulinastatin was also able to delay the occurrence of … Display
full size … ulinastatin could also persistently inhibit formalin-induced paw edema and ulcer …
full size … ulinastatin could also persistently inhibit formalin-induced paw edema and ulcer …
Anti-inflammatory and antinociceptive effects, and safety toxicological profile of a new paracetamol analog, LQFM291
LC Turones, LS Machado, BG Vaz… - …, 2023 - Springer
… paracetamol showed a similar antinociceptive effect in formalin test compared to LQFM291.
… and edema tests were performed, paracetamol showed a delayed antinociceptive and anti-…
… and edema tests were performed, paracetamol showed a delayed antinociceptive and anti-…
[HTML][HTML] … of Cajanus cajan (L) Millsp. produced antinociceptive and anti-inflammatory actions through inhibition of inflammatory mediators and activation of opioidergic …
TG Olubodun-Obadun, IO Ishola, CA Osumuo… - Phytomedicine Plus, 2023 - Elsevier
… the early and late phases of formalin-induced inflammatory pain… , we did not observe any
sign of toxic behaviour nor delayed … In this study, the oedema formation was maximal at 5 h after …
sign of toxic behaviour nor delayed … In this study, the oedema formation was maximal at 5 h after …
The antinociceptive effect of adalimumab, a TNF-alpha inhibitor, in a mice model of inflammatory pain
ÖZ Mehmet, H Şimşek - Türk Doğa ve Fen Dergisi, 2020 - dergipark.org.tr
… pulmonary edema and histological damage due to … This test is based on recording the
delay in the experimental … adalimumab has an antinociceptive effect in the formalin test. …
delay in the experimental … adalimumab has an antinociceptive effect in the formalin test. …
Neo-clerodane diterpenic influence in the antinociceptive and anti-inflammatory properties of Salvia circinnata Cav.
MP Fernando, HL Alberto, VDM Guadalupe… - Journal of …, 2021 - Elsevier
… using the plantar test and carrageenan-induced edema. The … was a beam emitted by a
caloric source with an intensity of … treatments in the formalin test in contrast to a delay of almost …
caloric source with an intensity of … treatments in the formalin test in contrast to a delay of almost …
[HTML][HTML] The CB2 agonist β-caryophyllene in male and female rats exposed to a model of persistent inflammatory pain
I Ceccarelli, P Fiorenzani, F Pessina, J Pinassi… - Frontiers in …, 2020 - frontiersin.org
… injection site were graded as mild (low degree of edema and … next painful events, we carried
out two formalin tests separated … a delay in wound healing (as in the present study) and may …
out two formalin tests separated … a delay in wound healing (as in the present study) and may …
[HTML][HTML] Anti-inflammatory, antinociceptive and antidiarrhoeal activities of methanol and ethyl acetate extract of Hemigraphis alternata leaves in mice
… induced ear edema in Swiss albino mice are documented in Table 2. The percentage of ear
… Formalin induced-paw licking is the biphasic pain response system. In the delayed phase, …
… Formalin induced-paw licking is the biphasic pain response system. In the delayed phase, …
Antinociceptive and anti-inflammatory effect of Naringenin in different nociceptive and inflammatory mice models
N Xue, X Wu, L Wu, L Li, F Wang - Life sciences, 2019 - Elsevier
… Carrageenan-induced paw edema test was performed to … The analgesics morphine delays
the tail withdrawal of mice from … significantly decreased the number formalin induced licks in …
the tail withdrawal of mice from … significantly decreased the number formalin induced licks in …